And Wilmer took that to heart, too, because her book is not only about musical form and expression, but also about the lives of musicians. It should be obvious that . This is the third in a series of essays about the 2018 World Cup. I not here to debate the merits of this tactic. What I pointing out is that suicide bombing is a fundamentally different animal. This is a very specific grassroots guerilla warfare tactic, designed to invoke fear among the victim society, and not to disable any strategic military objective or force capitulation from armed conflict..
The biggest question remaining involves the size of that bullpen, which will include seven pitchers if the Nationals take a six man bench like they did last year, and eight if they take the traditional five man bench. If the bullpen is eight pitchers deep, Enny Romero and Joe Blanton will likely both be in it. If it is seven pitchers deep, one of them will likely sit out..
Are you, or have you ever been, a vector? In both the bacteriological and physical senses of this strange word, the answer has to be yes. Vector in Latin just means carrier. We move around in a cloud of billions of personal microbes, but only rarely do these harm other people.
Saldana self identifies as Latina and black. Her father is Dominican, her mother is Puerto Rican. In a 2013 interview with the website HipHollywood, she stood up for herself.. A: No. The bird flu virus that has infected a few dozen people in Asia and the Middle East is not the same as the one that would ultimately create a human pandemic. Since it’s not known what the pandemic flu virus will look like, a vaccine against it can’t be made yet..
AHLUWALIA: I look, I respect John Lewis and his contribution and dedication to serving American public, but I feel well, he disparaged the American people, the American people who work for Donald Trump. And, overwhelmingly, he’s now the president elect. So nobody’s talking about that.
I was recently widowed. My estranged husband and I had been living apart for three years. I live in a very small place. I also went to my son’s room, thinking he had his TV on, it was also off. There was no apparent logical reason for the voices. I don’t consider myself crazy, and I do not do drugs..
Could the same benefits be translated to those without established CVD (the majority of the patient population we see in clinical practice)? CANVAS PROGRAM was supposed to answer this vital question in addition to assessing CV outcomes in those with established CVD.What was the clinical impact of CANVAS PROGRAM?The only end points in which canagliflozin came out with flying colours were MACE hospitalisation due to heart failure.MACE benefits in only those with established CVD (mimicking EMPA REG trial).No reduction in all cause mortality.No reduction in CV deaths.Significant increase in rates of fractures lower limb amputations.To summarise treating patients with canagliflozin results in:23 fewer MACE (? clinical implication: in the absence of any superiority of the individual end points), 16 fewer hospitalisation due to heart failure, at the cost of 15 more amputations per 1000 patients treated for 5 years (1).Where does that leave us with?In a desperate bid to save the molecule there is an effort to generalise the amputation risk aspect.There is no escaping the fact that the amputation fracture related issue was haunting canagliflozin well before the CANVAS PROGRAM was published (indicated by the black box warnings).What was brought out in the forefront was an EMEA observation of imbalances in the amputation rates in females in the EMPA REG trial (4). Although the EMEA statements were contradictory, they wanted to scrutinise the entire empagliflozin dapagliflozin data before painting this entire class of molecules with the same brush.In July 19th 2017, the entire empagliflozin databank from phase 2 3 EMPA REG were analysed and there was no signal of either increased amputation nor fracture risk (5).Similarly the entire dapagliflozin polled phase 2 3 data did not indicate any adverse signals related to amputation fracture (6).So where do we stand as of now?Empagliflozin remains the gold standard therapy for all type 2 diabetes patients with established CVD with a very reassuring safety profile.Dapagliflozin has also documented its CV safety in polled phase 2 3 trials. Further clarifications will be available after publication oF DECLARE TIMI 58 results..